The chemical modifications (CMs) of protein is an important technique in chemical biology,
protein‐based therapy, and material science. In recent years, there has been rapid …

Recently, owing to their special spatial structures, peptide-based macrocycles have shown
tremendous promise and aroused great interest in multidisciplinary research ranging from …

Abstract α‐Ketoaldehydes play versatile roles in the ubiquitous natural processes of protein
glycation. However, leveraging the reactivity of α‐ketoaldehydes for biomedical applications …

Peptide stapling reactions represent powerful methods for structuring native α-helices to
improve their bioactivity in targeting protein–protein interactions (PPIs). In light of a growing …

Due to their high specificity, peptides are promising candidates in drug development, but fast
degradation often limits their biological activity. Thus, a short half-life is one of the major …

Protein–protein interactions (PPIs) pose challenges for intervention through small molecule
drugs, protein drugs, and linear peptides due to inherent limitations such as inappropriate …