Adipocytokines are hormonally active molecules that are believed to play a key role in the
regulation of crucial biological processes in the human body. Numerous experimental …

Abstract Apelin and Elabela (Ela) are peptides encoded by APLN and APELA, respectively,
which act on their receptor APJ and play crucial roles in the body. Recent research has …

The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

Background Preeclampsia is a placentally induced syndrome with diverse clinical
presentation that currently has no cure. Oxidative stress is a potent inducer of placental …

Objective To investigate the regulatory mechanism of Apelin-13-mediated PI3K/AKT
signaling pathway in the glucose and lipid metabolism of gestational diabetes mellitus …

The apelinergic system, which includes the apelin receptor (APJ) as well as its two specific
ligands, namely apelin and ELABELA (ELA/APELA/Toddler), have been the subject of many …

Cardiovascular disease is the leading cause of death worldwide. Its prevalence is rising due
to ageing populations and the increasing incidence of diseases such as chronic kidney …

Although considerable success has been shown for antihypertensive medications, the
resistant hypertension and hypertension-related organ damages are still the important …

Objective This study investigates the correlation between serum apelin and galectin-3 levels
with insulin resistance (IR) in women with preeclampsia (PE). Methods Serum apelin …

The entire maternal circulation adapts to pregnancy, and this adaption is particularly
extensive in the uterine circulation where the major vessels double in size to facilitate an …