The Aurora kinases (A, B, and C) are a family of three isoform serine/threonine kinases that
regulate mitosis and meiosis. The Chromosomal Passenger Complex (CPC), which contains …

Mitotic cells face the challenging tasks of linking kinetochores to growing and shortening
microtubules and actively regulating these dynamic attachments to produce accurate …

The Aurora kinases are essential for the regulation of chromosome segregation and
cytokinesis during mitosis. Aberrant expression and activity of these kinases occur in a wide …

ABSTRACT TACC3 is the most oncogenic member of the transforming acidic coiled-coil
domain-containing protein (TACC) family. It is one of the major recruitment factors of distinct …

The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has
essential regulatory roles at centromeres and the central spindle in mitosis. Here, we …

Precise control of the attachment strength between kinetochores and spindle microtubules is
essential to preserve genomic stability. Aurora B kinase has been implicated in regulating …

Centrosomes act as sites of microtubule growth, but little is known about how the number
and stability of microtubules emanating from a centrosome are controlled during the cell …

How living systems break symmetry in an organized manner is a fundamental question in
biology. In wild-type Caenorhabditis elegans zygotes, symmetry breaking during anterior …

Many cancer cells contain more than two centrosomes, which imposes a potential for
multipolar mitoses, leading to cell death. To circumvent this, cancer cells develop …

Aurora-A, a mitotic serine/threonine kinase with oncogene characteristics, has recently
drawn intense attention because of its association with the development of human cancers …