Congenital cataracts, the most common cause of visual impairment and blindness in
children worldwide, have diverse etiologies. According to statistics analysis, about one …

The βγ-crystallins are among the most stable and long-lived proteins in the human body.
With increasing age, however, they transform to high molecular weight light-scattering …

The human lens is comprised largely of crystallin proteins assembled into a highly ordered,
interactive macro-structure essential for lens transparency and refractive index. Any …

The magnitude of cataract pathology is indeed significant as it is the principal cause of
blindness worldwide. Also, the prominence of this concept escalates with the current aging …

Abstract γS-crystallin is particularly rich in the embryonic nuclear region and is crucial to the
maintenance of lens transparency and optical properties. Gene mutations in crystallin are …

Abstract β/γ-Crystallins are predominant structural proteins in the cytoplasm of lens fiber
cells and share a similar fold composing of four Greek-key motifs divided into two domains …

Abstract β/γ-Crystallins, the predominant structural proteins in vertebrate lens with lifelong
stability to maintain lens transparency, share a high similarity in their primary sequences and …

Variations in proteins have very large number of diverse effects affecting sequence,
structure, stability, interactions, activity, abundance and other properties. Although protein …

Introduction Severe protein clumping in the lens can block light and lead to vision issues in
cataract patients. Recent studies have linked β-crystallins, which are key proteins in the lens …

The eye lens is crucial for proper vision via its role in refraction and focusing of light onto the
retina. The lens is a unique and unusual organ–its light refraction and transparency are …