The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Acute graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow
transplantation (BMT), limits the application of this curative but toxic therapy. Studies of …

Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease where invasive
pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that …

Introduction: The P2X7 receptor (P2X7R) has an important role in inflammation and
immunity, but until recently, clinical application has been limited by a lack of specific …

The angiogenic growth factor angiopoietin 2 (Ang2) destabilizes blood vessels, enhances
vascular leak and induces vascular regression and endothelial cell apoptosis. We …

Inflammation refers to a complex set of mechanisms by which tissues respond to injury and
infection. Among the many soluble mediators associated with this process, cytokines are …

Chronic age-related degenerative disorders, including the formation of chronic leg wounds,
may occur due to aging of the stromal tissues and ensuing dysfunctional cellular responses …

Hyperoxic lung injury is commonly encountered in patients who require treatment with high
concentrations of inspired oxygen. To determine whether interleukin (IL)-6 is protective in …

Exposure to high oxygen concentration causes direct oxidative cell damage through
increased production of reactive oxygen species. In vivo oxygen‐induced lung injury is well …