Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …

Hepatic macrophages are central in the pathogenesis of chronic liver injury and have been
proposed as potential targets in combatting fibrosis. Recent experimental studies in animal …

Macrophages are found in close proximity with collagen-producing myofibroblasts and
indisputably play a key role in fibrosis. They produce profibrotic mediators that directly …

Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation
and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the …

Objective Monocyte chemoattractant protein-1 (MCP-1, CCL2), the primary ligand for
chemokine receptor C–C chemokine receptor 2 (CCR2), is increased in livers of patients …

Chronic liver inflammation drives hepatic fibrosis, and current immunosuppressive, anti-
inflammatory, and anti-viral therapies can weaken this driver. Hepatic fibrosis is reversed …

Certain macrophage phenotypes contribute to tissue fibrosis, but why? Tissues host resident
mononuclear phagocytes for their support to maintain homeostasis. Upon injury the …

Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver
fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that …