Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Adenosine is a purine nucleoside, responsible for the regulation of multiple physiological
and pathological cellular and tissue functions by activation of four G protein-coupled …

Improvements in neuronal plasticity are considered to be conducive to recovery from
neuropathic pain. Electroacupuncture (EA) is regarded as an effective rehabilitation method …

Sleep deprivation (SD) is a common issue in today's society. Sleep is essential for proper
cognitive functions, including learning and memory. Furthermore, sleep disorders can alter …

Sleep is a circadian rhythm that is modulated by endogenous circadian clock located in the
suprachiasmatic nucleus (SCN). Sleep modulates memory acquisition and promotes …

Despite successful research efforts aimed at understanding pain mechanisms, there is still
no adequate treatment for many patients suffering from chronic pain. The contribution of …

Endometriosis is an estrogen-dependent gynecological disease, with an associated chronic
inflammatory component, characterized by the presence of endometrial tissue outside the …

Neural systems play important roles in the functions of acupuncture. But the unclear
structure and mechanism of acupoints hinder acupuncture standardization and cause the …

Neuropathic pain is a critical burdensome problem due to the complex interplay of several
pathological mechanisms and lack of availability of effective therapeutic interventions. The …

Background The efficacy of acupuncture at Zusanli (ST36) in alleviating lower-limb pain is
widely acknowledged in clinical practice, while its underlying mechanism remains …