Spasticity and its contribution to hypertonia in cerebral palsy

L Bar-On, G Molenaers, E Aertbeliën… - BioMed research …, 2015 - Wiley Online Library
Spasticity is considered an important neural contributor to muscle hypertonia in children with
cerebral palsy (CP). It is most often treated with antispasticity medication, such as Botulinum …

Science-based neurorehabilitation: recommendations for neurorehabilitation from basic science

JB Nielsen, M Willerslev-Olsen… - Journal of motor …, 2015 - Taylor & Francis
Neuroscience has fundamentally changed the understanding of learning and memory within
recent years. Here, the authors discuss a number of specific areas where they believe new …

Physics-based simulations to predict the differential effects of motor control and musculoskeletal deficits on gait dysfunction in cerebral palsy: a retrospective case …

A Falisse, L Pitto, H Kainz, H Hoang… - Frontiers in human …, 2020 - frontiersin.org
Physics-based simulations of walking have the theoretical potential to support clinical
decision-making by predicting the functional outcome of treatments in terms of walking …

Gait training facilitates central drive to ankle dorsiflexors in children with cerebral palsy

M Willerslev-Olsen, TH Petersen, SF Farmer… - Brain, 2015 - academic.oup.com
Foot drop and toe walking are frequent concerns in children with cerebral palsy. The main
underlying cause of these problems is early damage and lack of maturation of the …

Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood

MM Beck, ME Spedden, J Lundbye-Jensen - Scientific Reports, 2021 - nature.com
How does the neural control of fine movements develop from childhood to adulthood? Here,
we investigated developmental differences in functional corticomuscular connectivity using …

Stretching interventions in children with cerebral palsy: why are they ineffective in improving muscle function and how can we better their outcome?

BM Kalkman, L Bar-On, TD O'Brien… - Frontiers in …, 2020 - frontiersin.org
Hyper-resistance at the joint is one of the most common symptoms in children with cerebral
palsy (CP). Alterations to the structure and mechanical properties of the musculoskeletal …

A spasticity model based on feedback from muscle force explains muscle activity during passive stretches and gait in children with cerebral palsy

A Falisse, L Bar-On, K Desloovere, I Jonkers… - PloS one, 2018 - journals.plos.org
Muscle spasticity is characterized by exaggerated stretch reflexes and affects about 85% of
the children with cerebral palsy. However, the mechanisms underlying spasticity and its …

Impaired gait function in adults with cerebral palsy is associated with reduced rapid force generation and increased passive stiffness

SS Geertsen, H Kirk, J Lorentzen, M Jorsal… - Clinical …, 2015 - Elsevier
Objective It is still not clarified whether spasticity contributes to impairments of gait function.
Here we compared biomechanical measures of muscle weakness and stiffness of ankle …

The orthopaedic aspect of spastic cerebral palsy

VC Skoutelis, AD Kanellopoulos… - Journal of …, 2020 - Elsevier
Abstract Spastic Cerebral Palsy (CP) is the most common form of CP, comprising of 80% of
all cases. Spasticity is a type of hypertonia that clinically manifests as dynamic contractures …

Home-based versus laboratory-based robotic ankle training for children with cerebral palsy: a pilot randomized comparative trial

K Chen, YN Wu, Y Ren, L Liu, D Gaebler-Spira… - Archives of physical …, 2016 - Elsevier
Objective To examine the outcomes of home-based robot-guided therapy and compare it to
laboratory-based robot-guided therapy for the treatment of impaired ankles in children with …