Early neurodevelopment of HIV-exposed uninfected children in the era of antiretroviral therapy: a systematic review and meta-analysis

CJ Wedderburn, E Weldon, C Bertran-Cobo… - The Lancet Child & …, 2022 - thelancet.com
Background There are 15· 4 million children who are HIV-exposed and uninfected
worldwide. Early child development crucially influences later academic and socioeconomic …

Chronic comorbidities in children and adolescents with perinatally acquired HIV infection in sub-Saharan Africa in the era of antiretroviral therapy

LJ Frigati, W Ameyan, MF Cotton… - The Lancet Child & …, 2020 - thelancet.com
Summary Globally, 1· 7 million children are living with HIV, of which 90% are in sub-Saharan
Africa. The remarkable scale-up of combination antiretroviral therapy has resulted in …

African multi-site 2-year neuropsychological study of school-age children perinatally infected, exposed, and unexposed to human immunodeficiency virus

MJ Boivin, M Chernoff, L Fairlie… - Clinical Infectious …, 2020 - academic.oup.com
Background Children living with human immunodeficiency virus (HIV) are at
neuropsychological risk for cognitive and motor dysfunction. However, few prospective, multi …

Cognitive outcomes at ages seven and nine years in South African children from the children with HIV early antiretroviral (CHER) trial: a longitudinal investigation

KS van Wyhe, B Laughton, MF Cotton… - Journal of the …, 2021 - Wiley Online Library
Introduction Many children living with HIV (CLWH) display impaired cognition. Although
early combination antiretroviral therapy (ART) produces improved cognitive outcomes, more …

A neurometabolic pattern of elevated myo-inositol in children who are HIV-exposed and uninfected: A South African birth cohort study

C Bertran-Cobo, CJ Wedderburn… - Frontiers in …, 2022 - frontiersin.org
Introduction Exposure to maternal HIV in pregnancy may be a risk factor for impaired child
neurodevelopment during the first years of life. Altered neurometabolites have been …

Early antiretroviral therapy reduces severity but does not eliminate neurodevelopmental compromise in children with HIV

S Benki-Nugent, N Tamasha, A Mueni… - JAIDS Journal of …, 2023 - journals.lww.com
Background: Early antiretroviral therapy (ART) during infancy reduces cognitive impairment
due to HIV, but the extent of benefit is unclear. Setting: Children were recruited from hospital …

Gen Z and HIV—Strategies for Optimizing the Care of the Next Generation of Adolescents Living with HIV

I Dufour, Y Fougère, T Goetghebuer, M Hainaut… - Viruses, 2023 - mdpi.com
The management of adolescents living with HIV represents a particular challenge in the
global response to HIV. The challenges specific to this age group include difficulties …

[HTML][HTML] MRS suggests multi-regional inflammation and white matter axonal damage at 11 years following perinatal HIV infection

AS Graham, MJ Holmes, F Little, E Dobbels… - NeuroImage: Clinical, 2020 - Elsevier
The neurological changes in children living with perinatal HIV (PHIV) on antiretroviral
therapy (ART) can be studied at a metabolic level through proton magnetic resonance …

Increased risk of executive function and emotional behavioral problems among virologically well-controlled perinatally HIV-infected adolescents in Thailand and …

SJ Kerr, T Puthanakit, KM Malee… - JAIDS Journal of …, 2019 - journals.lww.com
Background: Large numbers of perinatally HIV-infected (PHIV) children are aging into
adolescence. We examined cognitive and behavioral outcomes in a longitudinal cohort of …

Neurocognitive development in perinatally human immunodeficiency virus–infected adolescents on long-term treatment, compared to healthy matched controls: A …

M Van den Hof, AM Ter Haar… - Clinical Infectious …, 2020 - academic.oup.com
Background A cross-sectional analysis of the Neurological, cOgnitive and VIsual
performance in hiv-infected Children cohort showed significant cognitive impairment in …