Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms

B Brown, V Ojha, I Fricke, SA Al-Sheboul, C Imarogbe… - Vaccines, 2023 - mdpi.com
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Neutrophils and macrophages as targets for development of nanotherapeutics in inflammatory diseases

Y Su, J Gao, P Kaur, Z Wang - Pharmaceutics, 2020 - mdpi.com
Neutrophils and macrophages are major components of innate systems, playing central
roles in inflammation responses to infections and tissue injury. If they are out of control …

Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes

F Ferraro, CA Miller, KA Christensen… - Proceedings of the …, 2021 - National Acad Sciences
Acute myeloid leukemia (AML) patients rarely have long first remissions (LFRs;> 5 y) after
standard-of-care chemotherapy, unless classified as favorable risk at presentation …

Biodegradable mesoporous silica achieved via carbon nanodots-incorporated framework swelling for debris-mediated photothermal synergistic immunotherapy

M Qian, L Chen, Y Du, H Jiang, T Huo, Y Yang… - Nano Letters, 2019 - ACS Publications
Incorporating carbon nanodots (CDs) into mesoporous silica framework for extensive
biomedicine, especially for the desirable cancer immunotherapy, is considered to be an …

The mannose receptor: from endocytic receptor and biomarker to regulator of (meta) inflammation

HJP van der Zande, D Nitsche, L Schlautmann… - Frontiers in …, 2021 - frontiersin.org
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and
internalize a variety of endogenous and pathogen-associated ligands. Because of these …

[HTML][HTML] Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators

M Pastore, A Caligiuri, C Raggi, N Navari, B Piombanti… - JHEP Reports, 2022 - Elsevier
Background & Aims Activation of Kupffer cells and recruitment of monocytes are key events
in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic …

Successful classification of macrophage-mannose receptor CD206 in severity of anti-MDA5 antibody positive dermatomyositis associated ILD

Y Horiike, Y Suzuki, T Fujisawa, H Yasui… - …, 2019 - academic.oup.com
Objectives Macrophage-mannose receptor, CD206, is a marker of alternatively activated
macrophages. Activated macrophages play key roles in DM. Interstitial lung disease (ILD) is …

Thick pcl fibers improving host remodeling of pgs‐pcl composite grafts implanted in rat common carotid arteries

J Fu, M Wang, I De Vlaminck, Y Wang - Small, 2020 - Wiley Online Library
Vasculopathy and the consequential ischemia are major medical challenges. Grafting is an
effective treatment to vascular occlusion. However, autologous grafting, despite scarcity, is …

Drug delivery to macrophages: A review of nano-therapeutics targeted approach for inflammatory disorders and cancer

M Mukhtar, H Ali, N Ahmed, R Munir… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Macrophages are involved in the normal defense of the body; however, the
varying phenotypes of macrophages and imbalance in their ratio lead to the impairment of …

Inhalable mannosylated rifampicin–curcumin co-loaded nanomicelles with enhanced in vitro antimicrobial efficacy for an optimized pulmonary tuberculosis therapy

JM Galdopórpora, C Martinena, E Bernabeu, J Riedel… - Pharmaceutics, 2022 - mdpi.com
Among respiratory infections, tuberculosis was the second deadliest infectious disease in
2020 behind COVID-19. Inhalable nanocarriers offer the possibility of actively targeting anti …