Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Meiotic spindle assembly ensures proper chromosome segregation in oocytes. However,
the mechanisms behind spindle assembly in human oocytes remain largely unknown. We …

INTRODUCTION Mammalian embryos frequently develop abnormally, resulting in
miscarriages and genetic disorders such as Down syndrome. The major cause for aberrant …

ABSTRACT TACC3 is the most oncogenic member of the transforming acidic coiled-coil
domain-containing protein (TACC) family. It is one of the major recruitment factors of distinct …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is capable of inducing a variety of biological
effects, and the regulation of the Nrf2 signaling pathway is closely related to longevity. To …

The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and
its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic …

Errors during meiotic resumption in oocytes can result in chromosome missegregation and
infertility. Several cell cycle kinases have been linked with roles in coordinating events …

Aurora kinase A and B share great similarity in sequences, structures, and phosphorylation
motif, yet they show different localizations and play distinct crucial roles. The factors that …

The interaction between TACC3 (transforming acidic coiled coil protein 3) and the
microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is …

TACC3 regulates spindle organization during mitosis and also regulates centrosome‐
mediated microtubule nucleation by affecting γ‐Tubulin ring complexes. In addition, it …