Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Structural similarities and differences between the human and the mouse pancreas
Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …
research are typically extrapolated to humans, it is important to understand both similarities …
Alpha-, delta-and PP-cells: are they the architectural cornerstones of islet structure and co-ordination?
MF Brereton, E Vergari, Q Zhang… - … of Histochemistry & …, 2015 - journals.sagepub.com
Islet non-β-cells, the α-δ-and pancreatic polypeptide cells (PP-cells), are important
components of islet architecture and intercellular communication. In α-cells, glucagon is …
components of islet architecture and intercellular communication. In α-cells, glucagon is …
A method for the generation of human stem cell-derived alpha cells
The generation of pancreatic cell types from renewable cell sources holds promise for cell
replacement therapies for diabetes. Although most effort has focused on generating …
replacement therapies for diabetes. Although most effort has focused on generating …
An interactive ImageJ plugin for semi-automated image denoising in electron microscopy
J Roels, F Vernaillen, A Kremer, A Gonçalves… - Nature …, 2020 - nature.com
The recent advent of 3D in electron microscopy (EM) has allowed for detection of nanometer
resolution structures. This has caused an explosion in dataset size, necessitating the …
resolution structures. This has caused an explosion in dataset size, necessitating the …
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
Abstract β-arrestins are critical signalling molecules that regulate many fundamental
physiological functions including the maintenance of euglycemia and peripheral insulin …
physiological functions including the maintenance of euglycemia and peripheral insulin …
[HTML][HTML] 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
ID Pokrovskaya, S Yadav, A Rao, E McBride… - Research and practice …, 2020 - Elsevier
Background State‐of‐the‐art 3‐dimensional (3D) electron microscopy approaches provide a
new standard for the visualization of human platelet ultrastructure. Application of these …
new standard for the visualization of human platelet ultrastructure. Application of these …
Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells
MT Adams, JAM Dwulet, JK Briggs, CA Reissaus, E Jin… - Elife, 2021 - elifesciences.org
The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized
insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging …
insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging …
[HTML][HTML] Opportunities and challenges in building a spatiotemporal multi-scale model of the human pancreatic β cell
The construction of a predictive model of an entire eukaryotic cell that describes its dynamic
structure from atomic to cellular scales is a grand challenge at the intersection of biology …
structure from atomic to cellular scales is a grand challenge at the intersection of biology …
[HTML][HTML] Multimodule imaging of the hierarchical equine hoof wall porosity and structure
The equine hoof wall has a complex, hierarchical structure that can inspire designs of impact-
resistant materials. In this study, we utilized micro-computed tomography (μ-CT) and serial …
resistant materials. In this study, we utilized micro-computed tomography (μ-CT) and serial …