Background: Of all the psychiatric disorders associated with insomnia, depression is the
most common. It has been estimated that 90% of patients with depression complain about …

Several lines of evidence support the notion that a substantial reorganization of cortical
connections, involving a programmed synaptic pruning, takes place during adolescence in …

• We reviewed the literature on sleep in psychiatric disorders and evaluated the data by
meta-analysis, a statistical method designed to combine data from different studies. A total of …

BACKGROUND: Sleep spindles are thought to induce synaptic changes and thereby
contribute to memory consolidation during sleep. Patients with schizophrenia show dramatic …

Objective: High-density EEG during sleep represents a powerful new tool to reveal potential
abnormalities in rhythm-generating mechanisms while avoiding confounding factors …

The prefrontal cortex (PFC) consists of the cortex lying in front of the primary and secondary
motor cortex, and includes the dorsolateral and orbital areas, frontal eye fields, and Broca's …

There is growing experimental evidence that the relationship between psychiatric disorders
and sleep is complex and includes bidirectional causation. This article provides the …

Although schizophrenia (SZ) is defined by waking phenomena, abnormal sleep is a
common feature. In particular, there is accumulating evidence of a sleep spindle deficit …

The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …

Sleep disturbances are commonly observed in schizophrenia, including in chronic, early-
course, and first-episode patients. This has generated considerable interest, both in clinical …