[HTML][HTML] Insulin resistance: from mechanisms to therapeutic strategies

SH Lee, SY Park, CS Choi - Diabetes & metabolism journal, 2022 - synapse.koreamed.org
Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment

N Samsu - BioMed research international, 2021 - Wiley Online Library
Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …

Acarbose treatment affects the serum levels of inflammatory cytokines and the gut content of bifidobacteria in C hinese patients with type 2 diabetes mellitus: 阿卡波糖 …

B Su, H Liu, J Li, Y Sunli, B Liu, D Liu… - Journal of …, 2015 - Wiley Online Library
摘要背景: 研究对中国2 型糖尿病患者在常规治疗的基础上加用阿卡波糖后对患者粪便肠道菌群
及血清炎症因子的影响. 方法: 95 名2 型糖尿病患者在常规治疗的基础上随机分为两组, A 组59 …

Leptin and obesity: role and clinical implication

M Obradovic, E Sudar-Milovanovic, S Soskic… - Frontiers in …, 2021 - frontiersin.org
The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

Clinical application of intermittent fasting for weight loss: progress and future directions

KA Varady, S Cienfuegos, M Ezpeleta… - Nature Reviews …, 2022 - nature.com
Intermittent fasting diets have become very popular in the past few years, as they can
produce clinically significant weight loss. These diets can be defined, in the simplest of …

[HTML][HTML] Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links

OO Oguntibeju - International journal of physiology …, 2019 - ncbi.nlm.nih.gov
Diabetes mellitus has been recognised as one of the four major non-communicable
diseases that demands urgent attention from all key shareholders globally in an effort to …

Risk factors for the development of psoriasis

K Kamiya, M Kishimoto, J Sugai, M Komine… - International journal of …, 2019 - mdpi.com
Psoriasis is an immune-mediated genetic skin disease. The underlying pathomechanisms
involve complex interaction between the innate and adaptive immune system. T cells …

[HTML][HTML] Targeting PI3K/AKT signaling pathway in obesity

MS Savova, LV Mihaylova, D Tews, M Wabitsch… - Biomedicine & …, 2023 - Elsevier
Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

T Wang, C He - Cytokine & growth factor reviews, 2018 - Elsevier
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

Human blood vessel organoids as a model of diabetic vasculopathy

RA Wimmer, A Leopoldi, M Aichinger, N Wick… - Nature, 2019 - nature.com
The increasing prevalence of diabetes has resulted in a global epidemic. Diabetes is a
major cause of blindness, kidney failure, heart attacks, stroke and amputation of lower limbs …