Human DNA topoisomerase II is an important target in anticancer therapy. Despite the
clinical success of drugs that target topoisomerase II, the development of resistant cancer …

Pyridine (py) is an important heterocyclic compound and is an integral part of various natural
products. There are various medicines containing py ring system being available in the …

1. INTRODUCTION The length of straightened-out DNA in a single cell is nearly 2 m. In
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …

Cyclic organic compounds with several ether linkages in their structure are of much concern
in our daily life applications. Crown ethers (CEs) are generally heterocyclic and extremely …

A series of novel terpyridine-skeleton molecules containing conformational rigidity, 14
containing benzo [4, 5] furo [3, 2-b] pyridine core and 15 comprising chromeno [4, 3-b] …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …

DNA topoisomerases comprise a major aspect of basic cellular biology and are molecular
targets for a variety of drugs like antibiotics, antibacterials and anticancer drugs. They act by …

The reaction of one equivalents of 5‐acetylthiadiazole with one equivalent of aldehyde in
acetic acid and ammonium acetate yielded thiadiazolyl‐pyridine derivatives in a …

A new series of 2, 4-diphenyl-6-aryl pyridines containing hydroxyl group (s) at the ortho,
meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase …

An alternative process of Pd-catalyzed C-4 selective coupling of 2, 4-dichloropyridines with
boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in …