Predicting the effects of coding variants is a major challenge. While recent deep-learning
models have improved variant effect prediction accuracy, they cannot analyze all coding …

Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid
carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor …

MEN 1 is a rare hereditary cancer syndrome which manifests a variety of endocrine and non-
endocrine neoplasms and lesions. Growing knowledge of this condition in both its molecular …

Differences in bone mineral density (BMD) patterns have been recently reported between
multiple endocrine neoplasia type 1–related primary hyperparathyroidism (HPT/MEN1) and …

Context: Data are scarce on the penetrance of multiple endocrine neoplasia type 1 (MEN1)-
related nonfunctioning pancreatic neuroendocrine tumors (NF-PETs) and insulinomas in …

Objective Only few large families with multiple endocrine neoplasia type 1 (MEN1) have
been documented. Here, we aimed to investigate the clinical features of a seven-generation …

We briefly review the characteristics of pituitary tumors associated with multiple endocrine
neoplasia type 1. Multiple endocrine neoplasia type 1 is an autosomal-dominant disorder …

Purpose Multiple endocrine neoplasia type 1 (MEN1) is caused by germline inactivating
mutations of the MEN1 gene. Currently, no direct genotype–phenotype correlation is …

Background: The surgical treatment of primary hyperparathyroidism (HPT) in patients with
multiple endocrine neoplasia type 1 (MEN1) has evolved due the concern of permanent …

Background Loss-of-function germline MEN1 gene mutations account for 75–95% of
patients with multiple endocrine neoplasia type 1 (MEN1). It has been postulated that …