Recent years have observed significant advances in our understanding of how the
serine/threonine kinase target of rapamycin (TOR) controls key cellular processes such as …

Over the years, studies have focused on the transcriptional regulation of oncogenesis. More
recently, a growing emphasis has been placed on translational control. The Ras and Akt …

Circular RNAs (circRNAs) are generated from many protein-coding genes. Most accumulate
in the cytoplasm, but how circRNA localization or nuclear export is controlled remains …

Genome-wide studies have identified thousands of long noncoding RNAs (lncRNAs) lacking
protein-coding capacity. However, most lncRNAs are expressed at a very low level, and in …

Leukemia stem cells (LSCs) are thought to play a central role in the pathogenesis of acute
leukemia and likely contribute to both disease initiation and relapse. Therefore, identification …

The eukaryotic translation initiation factor eIF4E is elevated in 30% of malignancies
including M4/M5 subtypes of acute myeloid leukemia (AML). The oncogenic potential of …

This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical
node in an RNA regulon that impacts nearly every stage of cell cycle progression …

The eukaryotic translation initiation factor eIF4E is deregulated in many human cancers, and
its overexpression in cells leads to malignant transformation. Oncogenic properties of eIF4E …

The eukaryotic translation initiation factor eIF4E is dysregulated in a wide variety of human
cancers. In the cytoplasm, eIF4E acts in the rate-limiting step of translation initiation whereas …

The eukaryotic initiation factor 4E (eIF4E) plays a central role in the initiation of gene
translation and subsequent protein synthesis by binding the 5′ terminal mRNA cap …