Currently, cancer treatment mainly consists of surgery, radiotherapy, chemotherapy,
immunotherapy, and molecular targeted therapy, of which radiotherapy is one of the major …

Among breast cancer subtypes, the triple negative breast cancer (TNBC) has the worst
prognosis. In absence of any permitted targeted therapy, standard chemotherapy is the …

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with low
survival rate and a lack of biomarkers and targeted treatments. Here, we target pyruvate …

How cell metabolism regulates DNA repair is incompletely understood. Here, we define a
GTP-mediated signaling cascade that links metabolism to DNA repair and has significant …

Despite aggressive treatments, pancreatic ductal adenocarcinoma (PDAC) remains an
intractable disease, largely because it is refractory to therapeutic interventions. To overcome …

Simple Summary This review explores how radiotherapy disrupts critical metabolic
pathways in cancer cells. It highlights vulnerabilities in glucose metabolism, lipid synthesis …

Background Resistance to existing therapies is a significant challenge in improving
outcomes for glioblastoma (GBM) patients. Metabolic plasticity has emerged as an important …

Tumor metabolism has emerged as a hallmark of cancer and is involved in carcinogenesis
and tumor growth. Reprogramming of tumor metabolism is necessary for cancer cells to …

In order to reduce the cardiotoxicity of doxorubicin (DOX) and improve its antitumor effect,
dihydroartemisinin (DHA) and DOX prodrug (DOX-S-DHA) synthesized via a single sulfur …

Radiation therapy (RT) is an effective therapeutic modality in breast cancer used as part of
the standard of care to prevent locoregional recurrences and distant metastases …