Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Human accelerated regions (HARs) are the fastest-evolving sequences in the human
genome. When HARs were discovered in 2006, their function was mysterious due to scant …

Comparative studies of hominids have long sought to identify mutational events that shaped
the evolution of the human nervous system. However, functional genetic differences are …

Human accelerated regions (HARs) have been implicated in human brain evolution.
However, insight into the genes and pathways they control is lacking, hindering the …

Comparative studies of great apes provide a window into our evolutionary past, but the
extent and identity of cellular differences that emerged during hominin evolution remain …

Transcriptional enhancers orchestrate cell type-and time point-specific gene expression
programs. Genetic variation within enhancer sequences is an important contributor to …

Using machine learning (ML), we interrogated the function of all human-chimpanzee
variants in 2,645 human accelerated regions (HARs), finding 43% of HARs have variants …

Human neuropsychiatric disorders are associated with genetic and environmental factors
affecting the brain, which has been subjected to strong evolutionary pressures resulting in …

Ultraconserved elements (UCEs) are the most conserved regions among the genomes of
evolutionarily distant species and are thought to play critical biological functions. However …

Changes in gene regulation have been linked to the expansion of the human cerebral cortex
and to neurodevelopmental disorders, potentially by altering neural progenitor proliferation …