The glymphatic system: Current understanding and modeling

T Bohr, PG Hjorth, SC Holst, S Hrabětová, V Kiviniemi… - IScience, 2022 - cell.com
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep in humans

H Jang, GA Mashour, AG Hudetz, Z Huang - Nature communications, 2024 - nature.com
Consciousness requires a dynamic balance of integration and segregation in brain
networks. We report an fMRI-based metric, the integration-segregation difference (ISD) …

Decoupling between brain activity and cerebrospinal fluid movement in neurological disorders

X Liu - Journal of Magnetic Resonance Imaging, 2024 - Wiley Online Library
Recent research has identified a link between the global mean signal of resting‐state
functional MRI (fMRI) and macro‐scale cerebrospinal fluid movement, indicating the …

Neuroimaging-based evidence for sympathetic correlation between brain activity and peripheral vasomotion during pain anticipation

Z Xu, Z Soh, Y Kurota, Y Kimura, H Hirano… - Scientific Reports, 2024 - nature.com
Anticipation of pain engenders anxiety and fear, potentially shaping pain perception and
governing bodily responses such as peripheral vasomotion through the sympathetic …

Characterizing systemic physiological effects on the blood oxygen level dependent signal of resting‐state fMRI in time‐frequency space using wavelets

QN Lee, JE Chen, GJ Wheeler… - Human Brain Mapping, 2023 - Wiley Online Library
Systemic physiological dynamics, such as heart rate variability (HRV) and respiration
volume per time (RVT), are known to account for significant variance in the blood oxygen …

[HTML][HTML] Sex-specific age-related changes in glymphatic function assessed by resting-state functional magnetic resonance imaging

F Han, X Liu, Y Yang, X Liu - BioRxiv, 2023 - ncbi.nlm.nih.gov
The glymphatic system that clears out brain wastes, such as amyloid-β (Aβ) and tau, through
cerebrospinal fluid (CSF) flow may play an important role in aging and dementias. However …

Hierarchical fluctuation shapes a dynamic flow linked to states of consciousness

A Li, H Liu, X Lei, Y He, Q Wu, Y Yan, X Zhou… - Nature …, 2023 - nature.com
Consciousness arises from the spatiotemporal neural dynamics, however, its relationship
with neural flexibility and regional specialization remains elusive. We identified a …

Functional and effective connectivity analysis of drug-resistant epilepsy: a resting-state fMRI analysis

EJ Bacon, C Jin, D He, S Hu, L Wang, H Li… - Frontiers in …, 2023 - frontiersin.org
Objective Epilepsy is considered as a neural network disorder. Seizure activity in epilepsy
may disturb brain networks and damage brain functions. We propose using resting-state …

Functional MRI signals exhibit stronger covariation with peripheral autonomic measures as vigilance decreases

BP Gold, SE Goodale, C Zhao… - Imaging …, 2024 - direct.mit.edu
Vigilance naturally drifts over time, coinciding with marked changes in brain-wide functional
magnetic resonance imaging (fMRI) signals. Though the precise origins of these …

Traces of EEG-fMRI coupling reveals neurovascular dynamics on sleep inertia

ZJ Wang, HC Lee, CH Chuang, FC Hsiao, SH Lee… - Scientific Reports, 2024 - nature.com
Upon emergence from sleep, individuals experience temporary hypo-vigilance and
grogginess known as sleep inertia. During the transient period of vigilance recovery from …