Abstract Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses
broad cardiovascular and cerebrovascular protective actions and has been used in Asian …

In the past decades, the branch of complementary and alternative medicine based
therapeutics has gained considerable attention worldwide. Pharmacological efficacy of …

Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the
Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian …

Natural products and their semisynthetic derivatives continue to be an important source of
potential drug leads. Natural products and their analogues structures possess the …

Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …

Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

Tanshinone II-A (TSN) is the most abundant diterpene quinone isolated from Danshen
(Salvia miltiorrhiza), which has been used in treating cardiovascular diseases for more than …

Multidrug ABC transporters such as P-glycoprotein (P-gp/MDR1/ABCB1) and multidrug
resistance protein 1 (MRP1/ABCC1) play an important role in the extrusion of drugs from the …

Human cytochrome P450 1A2 (CYP1A2) is one of the major CYPs in the liver (&sim13%)
and metabolizes about 20% of clinically used drugs. CYP1A2 is a 515-residue protein with a …

Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal
herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the …