Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance
and perturbations of the developing microbiome. Early-life microbiome disruption increases …

Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical
symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of …

Importance Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS),
but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse …

Background Infections acquired in hospital are an important cause of morbidity and mortality
in very preterm infants. Several small trials have suggested that supplementing the enteral …

Bacterial infections are a major cause of mortality in preterm babies, yet our understanding
of early-life disease-associated immune dysregulation remains limited. Here, we combine …

Background Few population-level estimates of invasive neonatal infections have been
reported from sub-Saharan Africa. We estimated the national incidence risk, aetiology, and …

Objective To compare management recommendations of the National Institute for Health
and Care Excellence (NICE) guidelines with the Kaiser Permanente sepsis risk calculator …

Antibiotics are the most frequently prescribed drugs in neonatal intensive care units (NICUs)
due to the severity of complications accompanying neonatal sepsis. However, antimicrobial …

Sepsis, a dysregulated host response to infection, has been difficult to accurately define in
children. Despite a higher incidence, especially in neonates, a non-specific clinical …

Importance Antibiotic treatment saves lives in newborns with early-onset sepsis (EOS), but
unwarranted antibiotic use is associated with resistant bacteria and adverse outcomes later …