Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Stem cells therapy for spinal cord injury

M Gazdic, V Volarevic, CR Harrell… - International journal of …, 2018 - mdpi.com
Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously
healthy young adults. Current therapeutic strategies for SCI includes surgical …

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

M Capogrosso, FB Wagner, J Gandar, EM Moraud… - Nature …, 2018 - nature.com
Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait
kinematics are powerful methods for the study of locomotion and the improvement of motor …

A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation

D Ma, Y Zhao, L Huang, Z Xiao, B Chen, Y Shi, H Shen… - Biomaterials, 2020 - Elsevier
Microglia/macrophage mediated-inflammation, a main contributor to the microenvironment
after spinal cord injury (SCI), persists for a long period of time and affects SCI repair …

Experimental spinal cord injury and behavioral tests in laboratory rats

RU Ahmed, M Alam, YP Zheng - Heliyon, 2019 - cell.com
Traumatic spinal cord injury (SCI) results in some serious neurophysiological consequences
that alter healthy body functions and devastate the quality of living of individuals. To find a …

The immune microenvironment and tissue engineering strategies for spinal cord regeneration

Y Feng, Y Peng, J Jie, Y Yang, P Yang - Frontiers in Cellular …, 2022 - frontiersin.org
Regeneration of neural tissue is limited following spinal cord injury (SCI). Successful
regeneration of injured nerves requires the intrinsic regenerative capability of the neurons …

Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord …

S Han, Z Xiao, X Li, H Zhao, B Wang, Z Qiu, Z Li… - Science China Life …, 2018 - Springer
Traumatic spinal cord injury (SCI) is a major challenge in the clinic. In this study, we sought
to examine the synergistic effects of linear ordered collagen scaffold (LOCS) and human …

Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery

R Requejo-Aguilar, A Alastrue-Agudo, M Cases-Villar… - Biomaterials, 2017 - Elsevier
Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. Animal models
of acute SCI have provided evidence that transplantation of ependymal stem/progenitor cells …

Porcine spinal cord injury model for translational research across multiple functional systems

RU Ahmed, CA Knibbe, F Wilkins, LC Sherwood… - Experimental …, 2023 - Elsevier
Animal models are necessary to identify pathological changes and help assess therapeutic
outcomes following spinal cord injury (SCI). Small animal models offer value in research in …

Therapeutic potential of stem cells for treatment of neurodegenerative diseases

H Ahmadian-Moghadam, MS Sadat-Shirazi… - Biotechnology …, 2020 - Springer
Neurodegenerative diseases are caused by a loss of neurons within the peripheral or
central nervous system. Inadequate repairability in the central nervous system and failure of …