Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Effective drug therapy to optimally influence disease requires an understanding of a drug's
pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In …

Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major
depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the …

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …

Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome
P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 …

Information on drug absorption and disposition in infants and children has increased
considerably over the past 2 decades. However, the impact of specific age-related effects on …

Betablockers are widely used medications for a variety of indications, including heart
failure, myocardial infarction, cardiac arrhythmias, and hypertension. Genetic variability in …

OBJECTIVE: After prolonged opioid exposure, children develop opioid-induced
hyperalgesia, tolerance, and withdrawal. Strategies for prevention and management should …

Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …