NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among
exhausted CD8+ tumor-infiltrating lymphocytes, the terminally exhausted subset contributes …

Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …

The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF).
These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an …

Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

Metformin is the most prescribed drug for DM2, but its site and mechanism of action are still
not well established. Here, we investigated the effects of metformin on basolateral intestinal …

In addition to fatty acids, glucose and lactate are important myocardial substrates under
physiologic and stress conditions. They are metabolized to pyruvate, which enters …

Mitochondrial pyruvate carrier 1 regulates fatty acid syntha... : Hepatology Mitochondrial pyruvate
carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty …

The myocardium is metabolically flexible; however, impaired flexibility is associated with
cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial …