Abstract Purpose of Review Apoptosis is a major mechanism of cancer cell death. Thus,
evasion of apoptosis results in therapy resistance. Here, we review apoptosis modulators in …

The tumor suppressor gene TP53 is one of the most frequently mutated genes in human
cancer. The central role of the TP53 protein in several fundamental processes such as …

Precision medicine has transformed the way urothelial carcinoma is managed. However,
current practices are limited by the availability of tissue samples for genomic profiling and …

Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …

Over the past decades, striking progress has been made in the treatment of pediatric
leukemia, approaching 90% overall survival in children with acute lymphoblastic leukemia …

The identification and study of genetic alterations involved in various signaling pathways
associated with the pathogenesis of acute lymphoblastic leukemia (ALL) and the application …

The prognosis for B-cell precursor acute lymphoblastic leukemia patients with Mixed-
Lineage Leukemia (MLL) gene rearrangements (MLLr BCP-ALL) is still extremely poor …

Background: Cancer is a major global health problem with high mortality rate. Most of the
clinically used anticancer agents induce apoptosis through genotoxic stress at various …

The MDM2 oncogene is amplified and/or overexpressed in various human cancers and
elevated expression of MDM2 protein acts as a survival factor promoting cancer progression …

Schizophrenia (SZ) is a devastating brain disease that affects about 1% of world population.
Among the top genetic associations, zinc finger protein 804A (ZNF804A) gene encodes a …