Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that
are caused by prions and affect humans and many animal species. It is now widely accepted …

Prion diseases are infectious neurodegenerative diseases occurring in humans and animals
with an invariably lethal outcome. One fundamental mechanistic event in prion diseases is …

Key to understanding the epidemiology and pathogenesis of prion diseases, including
chronic wasting disease (CWD) of cervids, is determining the mode of transmission from one …

Soil may serve as an environmental reservoir for prion infectivity and contribute to the
horizontal transmission of prion diseases (transmissible spongiform encephalopathies …

Prion diseases are neurodegenerative conditions that cause extensive damage to nerve
cells within the brain and can be fatal. Some prion disease agents accumulate first in …

Mammalian prions are the infectious agents responsible for transmissible spongiform
encephalopathies (TSE), a group of fatal, neurodegenerative diseases, affecting both …

Efficient horizontal transmission is a signature trait of chronic wasting disease (CWD) in
cervids. Infectious prions shed into excreta appear to play a key role in this facile …

After oral exposure, prions are thought to enter Peyer's patches via M cells and accumulate
first upon follicular dendritic cells (FDCs) before spreading to the nervous system. How …

Transmissible spongiform encephalopathies are fatal neurodegenerative diseases that are
caused by unconventional pathogens and affect the central nervous system of animals and …