Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8+ T Cells
JA Rutigliano, S Sharma, MY Morris… - Journal of …, 2014 - Am Soc Microbiol
One question that continues to challenge influenza A research is why some strains of virus
are so devastating compared to their more mild counterparts. We approached this question …
are so devastating compared to their more mild counterparts. We approached this question …
Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells
How previous immunity influences immune memory recall and protection against related
flaviviruses is largely unknown, yet encounter with multiple flaviviruses in a lifetime is …
flaviviruses is largely unknown, yet encounter with multiple flaviviruses in a lifetime is …
Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans
T cell–mediated heterologous immunity to different pathogens is promising for the
development of immunotherapeutic strategies. Aspergillus fumigatus and Candida albicans …
development of immunotherapeutic strategies. Aspergillus fumigatus and Candida albicans …
NS1 DNA vaccination protects against Zika infection through T cell–mediated immunity in immunocompetent mice
The causal association of Zika virus (ZIKV) with microcephaly, congenital malformations in
infants, and Guillain-Barré syndrome in adults highlights the need for effective vaccines …
infants, and Guillain-Barré syndrome in adults highlights the need for effective vaccines …
Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways
YW Han, JY Choi, E Uyangaa, SB Kim, JH Kim… - PLoS …, 2014 - journals.plos.org
Japanese encephalitis (JE) is major emerging neurologic disease caused by JE virus. To
date, the impact of TLR molecules on JE progression has not been addressed. Here, we …
date, the impact of TLR molecules on JE progression has not been addressed. Here, we …
A synthetic peptide CTL vaccine targeting nucleocapsid confers protection from SARS-CoV-2 challenge in rhesus macaques
PE Harris, T Brasel, C Massey, CV Herst, S Burkholz… - Vaccines, 2021 - mdpi.com
Background: Persistent transmission of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has given rise to a COVID-19 pandemic. Several vaccines, conceived in …
(SARS-CoV-2) has given rise to a COVID-19 pandemic. Several vaccines, conceived in …
Mouse models of heterologous flavivirus immunity: a role for cross-reactive T cells
Most of the world is at risk of being infected with a flavivirus such as dengue virus, West Nile
virus, yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika …
virus, yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika …
Pivotal Role of Antibody and Subsidiary Contribution of CD8+ T Cells to Recovery from Infection in a Murine Model of Japanese Encephalitis
M Larena, M Regner, E Lee, M Lobigs - Journal of virology, 2011 - Am Soc Microbiol
The immunological correlates for recovery from primary Japanese encephalitis virus (JEV)
infection in humans and experimental animals remain poorly defined. To investigate the …
infection in humans and experimental animals remain poorly defined. To investigate the …
CD8 T cells protect adult naive mice from JEV-induced morbidity via lytic function
Following Japanese encephalitis virus (JEV) infection neutralizing antibodies are shown to
provide protection in a significant proportion of cases, but not all, suggesting additional …
provide protection in a significant proportion of cases, but not all, suggesting additional …
Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants
DW Trobaugh, C Sun, MD Dunn, DS Reed… - PLoS …, 2019 - journals.plos.org
Live attenuated vaccines (LAVs), if sufficiently safe, provide the most potent and durable anti-
pathogen responses in vaccinees with single immunizations commonly yielding lifelong …
pathogen responses in vaccinees with single immunizations commonly yielding lifelong …