Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …

Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …

Fat accumulation in the pancreas associated with obesity and the metabolic syndrome
(MetS) has been defined as “non-alcoholic fatty pancreas disease”(NAFPD). The aim of this …

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes
mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and …

Research from epidemiologic studies and experimental animal models provide insights into
the role of pancreatic steatosis in the development of pancreatic cancer. Epidemiologic data …

Integrative analyses of genome-wide association studies and gene expression data have
implicated many disease-critical tissues. However, co-regulation of genetic effects on gene …

Nonalcoholic fatty pancreas disease (NAFPD) describes a phenotype of pancreatic steatosis
(PS) that is not caused by alcohol consumption, viral infections, toxins, or congenital …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer, and it is
currently the third most common cause of cancer death in the USA Progress in the fight …

Metabolic syndrome comprises a set of risk factors that include abdominal obesity, impaired
glucose tolerance, hypertriglyceridemia, low high-density lipoprotein levels, and high blood …