Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

Background Senescence is a tumor suppressor mechanism activated in stressed cells to
prevent replication of damaged DNA. Senescent cells have been demonstrated to play a …

Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased
senescent cell burden in various tissues is a major contributor to aging and age-related …

The cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) pathway detects
cytosolic DNA to activate innate immune responses. Poly (ADP-ribose) polymerase …

Platinum-based drugs, and in particular cis-diamminedichloroplatinum (II)(best known as
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …

Homologous recombination (HR) comprises a series of interrelated pathways that function in
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …

Background Adjuvant cisplatin-based chemotherapy improves survival among patients with
completely resected non–small-cell lung cancer, but there is no validated clinical or biologic …

Structural changes to DNA severely affect its functions, such as replication and transcription,
and play a major role in age-related diseases and cancer. A complicated and entangled …

DNA interstrand crosslinks (ICLs), highly toxic lesions that covalently link the Watson and
Crick strands of the double helix, are repaired by a complex, replication-coupled pathway in …