The transition from genomics to phenomics in personalized population health
Modern health care faces several serious challenges, including an ageing population and
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …
2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Current insights and emerging trends in early-onset type 2 diabetes
Type 2 diabetes diagnosed in childhood or early adulthood is termed early-onset type 2
diabetes. Cases of early-onset type 2 diabetes are increasing rapidly globally, alongside …
diabetes. Cases of early-onset type 2 diabetes are increasing rapidly globally, alongside …
Ethnic differences between Asians and non-Asians in clustering-based phenotype classification of adult-onset diabetes mellitus: a systematic narrative review
JS Varghese, KMV Narayan - Primary care diabetes, 2022 - Elsevier
Several international studies have stratified people with diabetes into phenotypical clusters.
However, there has not been a systematic examination of the variation in these clusters …
However, there has not been a systematic examination of the variation in these clusters …
[HTML][HTML] Advancing the communication of genetic risk for cardiometabolic diseases: a critical interpretive synthesis
Background Genetics play an important role in risk for cardiometabolic diseases—including
type 2 diabetes, cardiovascular disease and obesity. Existing research has explored the …
type 2 diabetes, cardiovascular disease and obesity. Existing research has explored the …
[HTML][HTML] Integrating common risk factors with polygenic scores improves the prediction of type 2 diabetes
Y Timasheva, Z Balkhiyarova, D Avzaletdinova… - International Journal of …, 2023 - mdpi.com
We tested associations between 13 established genetic variants and type 2 diabetes (T2D)
in 1371 study participants from the Volga-Ural region of the Eurasian continent, and …
in 1371 study participants from the Volga-Ural region of the Eurasian continent, and …
Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populations
Background: Genome-wide polygenic risk scores (PRS) have shown high specificity and
sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven …
sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven …
[HTML][HTML] Recent advances in polygenic scores: translation, equitability, methods and FAIR tools
Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic
predisposition to disease, and many potentially clinically useful applications have been …
predisposition to disease, and many potentially clinically useful applications have been …
The Prospect of Genomic, Transcriptomic, Epigenetic and Metabolomic Biomarkers for The Personalized Prevention of Type 2 Diabetes and Cardiovascular Diseases
A Zeljkovic, M Mihajlovic, S Vujcic… - Current Vascular …, 2023 - ingentaconnect.com
Cardiometabolic diseases, such as type 2 diabetes mellitus (DM) and cardiovascular
disease (CVD), are a great health concern. The strategies aimed to increase awareness and …
disease (CVD), are a great health concern. The strategies aimed to increase awareness and …
[HTML][HTML] A Strategic Research Framework for Defeating Diabetes in India: A 21st-Century Agenda
KMV Narayan, JS Varghese, YS Beyh… - Journal of the Indian …, 2023 - Springer
Indian people are at high risk for type 2 diabetes (T2DM) even at younger ages and lower
body weights. Already 74 million people in India have the disease, and the proportion of …
body weights. Already 74 million people in India have the disease, and the proportion of …