Airway inflammation is a key aspect of diseases such as asthma. Several inflammatory
cytokines (eg, TNFα and IL-13) increase cytosolic Ca2+ ([Ca2+] cyt) responses to agonist …

Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of
smooth muscle contraction, both under healthy and diseased conditions. This brief review …

Maintenance of blood oxygen saturation dictates supplemental oxygen administration to
premature infants, but hyperoxia predisposes survivors to respiratory diseases such as …

Background: Premature infants are at increased risk for airway diseases, such as wheezing
and asthma, because of early exposure to risk factors including hyperoxia. As in adult …

Aims: Cigarette smoke (CS) in active smokers and second-hand smoke exposure
exacerbate respiratory disorders such as asthma and chronic bronchitis. While women are …

Cigarette smoke is a common environmental insult associated with increased risk of
developing airway diseases such as wheezing and asthma in neonates and children. In …

Airway inflammation is a hallmark of asthma, triggering airway smooth muscle (ASM)
hyperreactivity and airway remodeling. TNFα increases both agonist-induced cytosolic Ca2+ …

Enhanced airway smooth muscle (ASM) contractility contributes to increased resistance to
airflow in diseases such as bronchitis and asthma that occur in passive smokers exposed to …

Caveolae are flask-shaped plasma membrane invaginations expressing the scaffolding
caveolin proteins. Although caveolins have been found in endothelium and epithelium …

Background Airway inflammation and airway remodeling are the key contributors to airway
hyperresponsiveness (AHR), a characteristic feature of asthma. Both processes are …