Currently, neuropathic pain is an underestimated socioeconomic health problem affecting
millions of people worldwide, which incidence may increase in the next years due to …

Neuropathic pain following spinal cord injury (SCI) is notoriously difficult to treat and is a
high priority for many in the SCI population. Resolving this issue requires animal models …

Traumatic primary spinal cord injury (SCI) results in paralysis below the level of injury and is
associated with infiltration of hematogenous innate immune cells into the injured cord …

Trauma to the spinal cord and associated secondary inflammation can lead to permanent
loss of sensory and motor function below the injury level, with the resulting environment …

Recently, many clinical trials have challenged the efficacy of current therapeutics for
neuropathic pain after spinal cord injury (SCI) due to their life-threatening side-effects …

Reactive oxygen species (ROS) are thought to have a strong correlation with a number of
intervertebral disc (IVD) diseases. Here, we aimed to determine whether ROS represent an …

Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic
properties. This multifaceted drug has a number of pharmacological and neurochemical …

Currently there are no effective therapies available for the excruciating neuropathic pain that
develops after spinal cord injuries (SCI). As such, a great deal of effort is being put into the …

Aims/hypothesis Recent studies suggest that abnormal function in Müller glial cells plays an
important role in the pathogenesis of diabetic retinopathy. This is associated with the …

Background The mechanisms underlying lesions of dopaminergic (DA) neurons, an
essential pathology of Parkinson's disease (PD), are largely unknown, although oxidative …