Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …

Transposable elements are DNA segments with the unique ability to move about in the
genome. This inherent feature can be exploited to harness these elements as gene vectors …

Transposons have provided important genetic tools for functional genomic screens in lower
eukaryotes but have proven less useful in higher eukaryotes because of their low …

Abstract The Sleeping Beauty (SB) transposon is an emerging tool for transgenesis, gene
discovery, and therapeutic gene delivery in mammals. Here we studied 1,336 SB insertions …

Retroviral insertion mutagenesis screens in mice are powerful tools for efficient identification
of oncogenic mutations in an in vivo setting. Many oncogenes identified in these screens …

Comparison of two related species is one of the most successful approaches to decipher
general genetic principles in eukaryotes. This is best illustrated in yeast, where the model …

Abstract The Japanese medaka, Oryzias latipes, is a vertebrate teleost model with a long
history of genetic research. A number of unique features and established resources …

Background Among functional elements of a metazoan gene, enhancers are particularly
difficult to find and annotate. Pioneering experiments in Drosophila have demonstrated the …

Small fish are a popular laboratory model for studying gene expression and function by
transgenesis. If, however, the transgenes are not readily detectable by visual inspection, a …

Abstract The Sleeping Beauty (SB) transposon system represents a new vector for non‐viral
gene transfer that melds advantages of viruses and other forms of naked DNA transfer. The …