Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Central nervous system (CNS) is one of the largest killers of people's health all over the
world. The overactivation of the immune and inflammatory responses is considered as an …

Emerging evidence suggests that astrocyte loss is one of the most important pathological
features in the hippocampus of patients with major depressive disorder (MDD) and …

Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are
affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to …

During the last decade, substance use disorders (SUDs) have been increasingly recognized
as neuroinflammation-related brain diseases. Various types of abused drugs (cocaine …

Introduction Perinatal hypoxic-ischemic (HI) insult is an important cause of brain injury in
neonates. The development of novel treatment strategies for neonates with HI brain injury is …

NLRP6, the nucleotide oligomerization domain-like receptor family pyrin domain containing
6, has a substantiable effect on inflammation and host defense against microorganisms. In …

Inflammasomes are important modulators of inflammation. Dysregulation of inflammasomes
can enhance vulnerability to conditions such as neurodegenerative diseases …

Introduction In clinical settings, dairy cows are often attacked by pathogenic bacteria after
delivery, especially Staphylococcus aureus (S. aureus). Neutrophils have long been …

Evidence indicates that adverse experiences in early life may be a factor for immune
disturbances leading to the depression in adulthood. Recently, a pivotal role in the …