[HTML][HTML] Peptide-based supramolecular vaccine systems

CL O'Neill, PC Shrimali, ZE Clapacs, MA Files… - Acta biomaterialia, 2021 - Elsevier
Currently approved replication-competent and inactivated vaccines are limited by excessive
reactogenicity and poor safety profiles, while subunit vaccines are often insufficiently …

Supramolecular self-assembled peptide-based vaccines: current state and future perspectives

T Abdullah, K Bhatt, LJ Eggermont, N O'Hare… - Frontiers in …, 2020 - frontiersin.org
Despite the undeniable success of vaccination programs in preventing diseases, effective
vaccines against several life-threatening infectious pathogens such as human …

Next generation mucosal vaccine strategy for respiratory pathogens

F Dotiwala, AK Upadhyay - Vaccines, 2023 - mdpi.com
Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the
potential to prevent the infection from getting established. This is different from systemic …

10-Residue MyD88-peptide adopts β-sheet structure, self-Assembles, binds to lipopolysaccharides, and rescues mice from endotoxin-mediated lung-infection and …

T Kumari, DP Verma, J Kuldeep… - ACS Chemical …, 2022 - ACS Publications
Naturally occurring cationic antimicrobial peptides (AMPs) mostly adopt α-helical structures
in bacterial membrane mimetic environments. To explore the design of novel β-sheet AMPs …

A cutting-edge immunoinformatics approach for design of multi-epitope oral vaccine against dreadful human malaria

M Pritam, G Singh, S Swaroop, AK Singh… - International Journal of …, 2020 - Elsevier
Human malaria is a pathogenic disease mainly caused by Plasmodium falciparum, which
was responsible for about 405,000 deaths globally in the year 2018. To date, several …

[HTML][HTML] Targeting yezo virus structural proteins for multi-epitope vaccine design using immunoinformatics approach

S Rahman, CC Chiou, MM Almutairi, A Ajmal, S Batool… - Viruses, 2024 - mdpi.com
A novel tick-borne orthonairovirus called the Yezo virus (YEZV), primarily transmitted by the
Ixodes persulcatus tick, has been recently discovered and poses significant threats to …

A TLR7 agonist conjugated to a nanofibrous peptide hydrogel as a potent vaccine adjuvant

EM Euliano, BH Pogostin, A Agrawal… - Advanced …, 2024 - Wiley Online Library
Toll‐like receptors (TLRs) recognize pathogen‐and damage‐associated molecular patterns
and, in turn, trigger the release of cytokines and other immunostimulatory molecules. As a …

Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics

S Van Herck, BG De Geest - Acta Pharmacologica Sinica, 2020 - nature.com
The advent of immunotherapy is a game changer in cancer therapy with monoclonal
antibody-and T cell-based therapeutics being the current flagships. Small molecule …

Receptor-ligand based molecular interaction to discover adjuvant for immune cell TLRs to develop next-generation vaccine

N Gupta, H Regar, VK Verma, D Prusty, A Mishra… - International Journal of …, 2020 - Elsevier
Human immune cell toll-like receptors (TLRs) provide a novel chance for the development of
the vaccine adjuvant engaging TLR signaling. A library of peptides was developed and …

Self-assembling nano-globular peptide from human lactoferrin acts as a systemic enhancer of bone regeneration: A novel peptide for orthopedic application

S Pal, M Sayeed, A Kumar, DP Verma… - … Applied Materials & …, 2021 - ACS Publications
A technology for systemic and repeated administration of osteogenic factors for orthopedic
use is an unmet medical need. Lactoferrin (∼ 80 kDa), present in milk, is known to support …