Ambient mass spectrometry

RG Cooks, Z Ouyang, Z Takats, JM Wiseman - Science, 2006 - science.org
A recent innovation in mass spectrometry is the ability to record mass spectra on ordinary
samples, in their native environment, without sample preparation or preseparation by …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Intraoperative tissue identification using rapid evaporative ionization mass spectrometry

J Balog, L Sasi-Szabó, J Kinross, MR Lewis… - Science translational …, 2013 - science.org
Rapid evaporative ionization mass spectrometry (REIMS) is an emerging technique that
allows near–real-time characterization of human tissue in vivo by analysis of the aerosol …

Multi‐dimensional mass spectrometry‐based shotgun lipidomics and novel strategies for lipidomic analyses

X Han, K Yang, RW Gross - Mass spectrometry reviews, 2012 - Wiley Online Library
Since our last comprehensive review on multi‐dimensional mass spectrometry‐based
shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the …

Development, characterization, and application of paper spray ionization

J Liu, H Wang, NE Manicke, JM Lin, RG Cooks… - Analytical …, 2010 - ACS Publications
Paper spray is developed as a direct sampling ionization method for mass spectrometric
analysis of complex mixtures. Ions of analyte are generated by applying a high voltage to a …

Low-temperature plasma probe for ambient desorption ionization

JD Harper, NA Charipar, CC Mulligan… - Analytical …, 2008 - ACS Publications
A low-temperature plasma (LTP) probe has been developed for ambient desorption
ionization. An ac electric field is used to induce a dielectric barrier discharge through use of …

Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology

Z Takats, JM Wiseman… - Journal of mass …, 2005 - Wiley Online Library
Analytical characteristics of DESI are summarized. Examples of applications to small and
large molecules, to in situ analysis, and to high‐throughput analyses are presented …

A concise review of mass spectrometry imaging

ERA van Hove, DF Smith, RMA Heeren - Journal of chromatography A, 2010 - Elsevier
Mass spectrometric imaging allows the investigation of the spatial distribution of molecules
at complex surfaces. The combination of molecular speciation with local analysis renders a …

Diagnosis of prostate cancer by desorption electrospray ionization mass spectrometric imaging of small metabolites and lipids

S Banerjee, RN Zare, RJ Tibshirani… - Proceedings of the …, 2017 - National Acad Sciences
Accurate identification of prostate cancer in frozen sections at the time of surgery can be
challenging, limiting the surgeon's ability to best determine resection margins during …

Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry

JM Wiseman, DR Ifa, Q Song… - Angewandte Chemie …, 2006 - Wiley Online Library
Mass spectrometry (MS) is an increasingly indispensable tool in the biological sciences.
Innovations in methods of creating, analyzing (mass), dissociating, reacting, and collecting …