Simple Summary Bisphosphonates are a group of drugs that intervene in the bone
resorption process, producing cellular death of osteoclasts. These drugs are used for …

Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a relatively recently
described disorder of unknown etiology affecting the teeth of older horses. 1 The condition …

Bisphosphonates (BPs) are characterized by their ability to bind strongly to bone mineral
and inhibit bone resorption. However, BPs exert a wide range of pharmacological activities …

Background Clodronate is a potent antiresorptive agent labelled for use in horses over 4
years of age, for the treatment of navicular syndrome. Concerns regarding the extra‐label …

Two early observations about the first generation bisphosphonate, clodronate, suggested
that it would likely have clinical utility; specifically, it was a more potent anti-resorptive but a …

OBJECTIVE To compare the effects of tiludronate disodium and 3 other medical treatments
on clinical and radiographic findings and biomarkers of disease progression in horses with …

Background Allogeneic bone marrow‐derived mesenchymal stem cells (BMDMSCs) could
provide multiple advantages over autologous BMDMSCs, including creating an 'off‐the …

Bisphosphonates are a group of drugs that can reduce bone resorption by incorporating into
the crystal structure of exposed hydroxyapatite where they are taken up by osteoclasts …

The current experiment was designed to investigate the possible effects of acute blood loss
on the inflammatory and bone biomarkers status, acid-base balance, blood gases, and …

Background Clodronate is a non‐nitrogenated bisphosphonate approved for use in horses.
There are no peer‐reviewed published reports describing the pharmacokinetics or …