Extracellular phosphate regulates its own renal excretion by eliciting concentration-
dependent secretion of parathyroid hormone (PTH). However, the phosphate-sensing …

The salt bridge is the strongest non-covalent interaction in nature and is known to participate
in protein folding, protein-protein interactions, and molecular recognition. However, the role …

Biocatalysis for the synthesis of fine chemicals is highly attractive but usually requires
organic (co‐) solvents (OSs). However, native enzymes often have low activity and …

This study focuses on the intrinsically disordered regulatory domain of p53 and the impact of
post-translational modifications. Through fully atomistic explicit water molecular dynamics …

Abstract β-mannanases are pivotal enzymes that cleave the mannan backbone to release
short chain mannooligosaccharides, which have tremendous biotechnological applications …

In the early 2000s, the concept of “unstructured biology” has emerged to be an important
field in protein science by generating various new research directions. Many novel …

Protein stability can be fine‐tuned by modifying different structural features such as
hydrogen‐bond networks, salt bridges, hydrophobic cores, or disulfide bridges. Among …

The anti-PD-L1 monoclonal antibody (mAb) targeting PD-1/PD-L1 immune checkpoint has
achieved outstanding results in clinical application and has become one of the most popular …

The COVID-19 origin debate has greatly been influenced by genome comparison studies of
late, revealing the emergence of the Furin-like cleavage site at the S1/S2 junction of the …

COVID-19 is characterized by an unprecedented abrupt increase in the viral transmission
rate (SARS-CoV-2) relative to its pandemic evolutionary ancestor, SARS-CoV (2003). The …