Determining the structure and composition of macromolecular assemblies is a major
challenge in biology. Here we describe ultrastructure expansion microscopy (U-ExM), an …

Expansion microscopy (ExM) enables super-resolution fluorescence imaging of physically
expanded biological samples with conventional microscopes. By combining ExM with single …

The maturation of liquid-like protein condensates into amyloid fibrils has been associated
with several neurodegenerative diseases. However, the molecular mechanisms underlying …

The advent of super-resolution techniques in biological microscopy has opened new
frontiers for exploring the molecular distribution of proteins and small molecules in cells …

The synaptonemal complex (SC) is a meiosis-specific nuclear multiprotein complex that is
essential for proper synapsis, recombination and segregation of homologous chromosomes …

Second harmonic generation microscopy (SHG) is generally acknowledged as a powerful
tool for the label-free three-dimensional visualization of tissues and advanced materials …

Diabetic retinopathy (DR) is a severe ocular complication that causes retinal damage, being
one of the leading causes of blindness globally, thus the development of new strategies to …

Desmosomal cadherins, desmocollins, and desmogleins are cholesterol-dependent entities
responsible for the stable adhesion of desmosomes in epithelial cells. Here, we investigated …

We present a new flexible high speed laser scanning confocal microscope and its extension
by an astigmatism particle tracking velocimetry (APTV) device. Many standard confocal …

结构光照明显微镜(Structured Illumination Microscopy, SIM) 通过结构化照明在频率域以空间
混频的方式将物体高频信息载入光学系统的探测通带内实现突破衍射极限的超分辨光学显微 …