ABSTRACT GLI-Similar 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc
finger transcription factors that functions as an activator or repressor of gene expression …

With glucose being at the center of energy consumption and production, maintaining
homeostasis of this simple sugar is of pivotal importance. Loss of glucose homeostasis …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

The early stages of type 1 diabetes (T1D) are characterized by local autoimmune
inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show …

Pancreatic islets control glucose homeostasis by the balanced secretion of insulin and other
hormones, and their abnormal function causes diabetes or hypoglycaemia. Here we …

Nonalcoholic steatohepatitis (NASH) is an advanced stage of nonalcoholic fatty liver
disease (NAFLD) with serious consequences that currently lacks approved pharmacological …

Background Adult human pancreatic beta cells are the “gold standard” for studies on
diabetes pathogenesis, but their use is limited by insufficient availability and variable quality …

Aims/hypothesis The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may
contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and …

Despite novel therapeutic strategies, advanced-stage prostate cancer (PCa) remains highly
lethal, pointing out the urgent need for effective therapeutic strategies. While dysregulation …

We recently described the persistence of detectable serum proinsulin in a large majority of
individuals with longstanding type 1 diabetes (T1D), including individuals with undetectable …