[HTML][HTML] Pathogenesis of aging and age-related comorbidities in people with HIV: highlights from the HIV ACTION workshop

D Gabuzda, BD Jamieson, RG Collman… - Pathogens and …, 2020 - ncbi.nlm.nih.gov
People with HIV (PWH) experience accentuated biological aging, as defined by markers of
inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated …

Examining relationships between metabolism and persistent inflammation in HIV patients on antiretroviral therapy

D Ahmed, D Roy, E Cassol - Mediators of inflammation, 2018 - Wiley Online Library
With the advent of antiretroviral therapy (ART), HIV‐infected individuals are now living
longer and healthier lives. However, ART does not completely restore health and treated …

Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy

S Chettimada, DR Lorenz, V Misra, ST Dillon… - Scientific reports, 2018 - nature.com
Exosomes are nanovesicles released from most cell types including immune cells. Prior
studies suggest exosomes play a role in HIV pathogenesis, but little is known about …

Impact of comorbidity and ageing on health-related quality of life in HIV-positive and HIV-negative individuals

N Langebeek, KW Kooij, FW Wit, IG Stolte… - Aids, 2017 - journals.lww.com
Background: HIV-infected individuals may be at risk for the premature onset of age-
associated noncommunicable comorbidities. Being HIV-positive, having comorbidities and …

Impact of depression and inflammation on the progression of HIV disease

Y Rivera-Rivera, FJ Vázquez-Santiago… - Journal of clinical & …, 2016 - pmc.ncbi.nlm.nih.gov
The human immunodeficiency virus type 1 (HIV-1) epidemic has negatively affected over 40
million people worldwide. Antiretroviral therapy (ART) has improved life expectancy and …

A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression

HU Zacharias, J Hertel, H Johar, M Pietzner… - Molecular …, 2021 - nature.com
Depression constitutes a leading cause of disability worldwide. Despite extensive research
on its interaction with psychobiological factors, associated pathways are far from being …

Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in …

TL Emmerzaal, G Preston, B Geenen, V Verweij… - Translational …, 2020 - nature.com
Mitochondria play a critical role in bioenergetics, enabling stress adaptation, and therefore,
are central in biological stress responses and stress-related complex psychopathologies. To …

Methamphetamine and cannabis: a tale of two drugs and their effects on HIV, brain, and behavior

R Saloner, JA Fields, MCG Marcondes… - Journal of Neuroimmune …, 2020 - Springer
HIV infection and drug use intersect epidemiologically, and their combination can result in
complex effects on brain and behavior. The extent to which drugs affect the health of …

Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection

Y Takahashi, M Ueki, M Yamada, G Tamiya… - Translational …, 2020 - nature.com
To solve major limitations in algorithms for the metabolite-based prediction of psychiatric
phenotypes, a novel prediction model for depressive symptoms based on nonlinear feature …

Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection

M Cuperlovic-Culf, EL Cunningham, H Teimoorinia… - Scientific Reports, 2021 - nature.com
Delirium is an acute change in attention and cognition occurring in~ 65% of severe SARS-
CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and …