Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

R Patani, GE Hardingham, SA Liddelow - Nature Reviews Neurology, 2023 - nature.com
Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Function and therapeutic value of astrocytes in neurological diseases

HG Lee, MA Wheeler, FJ Quintana - Nature reviews Drug discovery, 2022 - nature.com
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

The glymphatic system: a novel component of fundamental neurobiology

LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

Astrocyte morphology

KT Baldwin, KK Murai, BS Khakh - Trends in cell biology, 2024 - cell.com
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal
feature of astrocytes is their complex and visually enchanting morphology, referred to as …

Astrocytes and microglia: in sickness and in health

ID Vainchtein, AV Molofsky - Trends in neurosciences, 2020 - cell.com
Healthy central nervous system (CNS) development and function require an intricate and
balanced bidirectional communication between neurons and glia cells. In this review, we …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

[HTML][HTML] Behaviorally consequential astrocytic regulation of neural circuits

J Nagai, X Yu, T Papouin, E Cheong, MR Freeman… - Neuron, 2021 - cell.com
Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

The emerging nature of astrocyte diversity

BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

[HTML][HTML] Cell biology of astrocyte-synapse interactions

NJ Allen, C Eroglu - Neuron, 2017 - cell.com
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …

Neural circuit-specialized astrocytes: transcriptomic, proteomic, morphological, and functional evidence

H Chai, B Diaz-Castro, E Shigetomi, E Monte… - Neuron, 2017 - cell.com
Astrocytes are ubiquitous in the brain and are widely held to be largely identical. However,
this view has not been fully tested, and the possibility that astrocytes are neural circuit …