Terpenoids' anti-cancer effects: Focus on autophagy

C El-Baba, A Baassiri, G Kiriako, B Dia, S Fadlallah… - Apoptosis, 2021 - Springer
Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

[HTML][HTML] Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

ZY Tang, Y Li, YT Tang, XD Ma, ZY Tang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Oleanolic acid (OA, 3 β-hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic
triterpenoid present in many plants. As a new framework for development of semi synthetic …

EGFR targeted albumin nanoparticles of oleanolic acid: In silico screening of nanocarrier, cytotoxicity and pharmacokinetics for lung cancer therapy

VN Shukla, AK Mehata, A Setia, P Kumari… - International Journal of …, 2023 - Elsevier
This study aimed to develop cetuximab (CTX) functionalized albumin nanoparticles (ALB-
NPs) of oleanolic acid for EGFR targeted lung cancer therapy. The molecular docking …

[HTML][HTML] Pentacyclic triterpene oleanolic acid protects against cardiac aging through regulation of mitophagy and mitochondrial integrity

Y Gong, Y Luo, S Liu, J Ma, F Liu, Y Fang, F Cao… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Advanced aging exhibits altered cardiac geometry and function involving mitochondrial
anomaly. Natural compounds display promises in the regulation of cardiac homeostasis via …

Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives

Y Chen, X Tan, W Zhang, Y Li, X Deng… - Phytotherapy …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC), presently the second leading cause of global cancer‐
related mortality, continues to pose significant challenges in the realm of medical oncology …

Development and evaluation of oleanolic acid dosage forms and its derivatives

A Feng, S Yang, Y Sun, L Zhang… - BioMed Research …, 2020 - Wiley Online Library
Oleanolic acid is a pentacyclic triterpenoid compound that exists widely in medicinal herbs
and other plants. Because of the extensive pharmacological activity, oleanolic acid has …

Recent advances regarding the molecular mechanisms of triterpenic acids: A review (part I)

M Mioc, A Milan, D Malița, A Mioc, A Prodea… - International Journal of …, 2022 - mdpi.com
Triterpenic acids are phytocompounds with a widespread range of biological activities that
have been the subject of numerous in vitro and in vivo studies. However, their underlying …

The potential application of chinese medicine in liver diseases: a new opportunity

K Fu, C Wang, C Ma, H Zhou, Y Li - Frontiers in Pharmacology, 2021 - frontiersin.org
Liver diseases have been a common challenge for people all over the world, which
threatens the quality of life and safety of hundreds of millions of patients. China is a major …

Carboxymethyl cellulose/Zn-organic framework down-regulates proliferation and up-regulates apoptosis and DNA damage in colon and lung cancer cell lines

A Negm, M Gouda, HIM Ibrahim - Polymers, 2022 - mdpi.com
A solvothermal technique was used to prepare a Zn–benzenetricarboxylic acid (Zn@ BTC)
organic framework covered with a carboxymethyl cellulose (CMC/Zn@ BTC). Fourier …

Therapeutic potential of oleanolic acid in liver diseases

Y Wang, K Liu - Naunyn-Schmiedeberg's Archives of Pharmacology, 2024 - Springer
Liver-associated diseases affect millions of individuals worldwide. In developed countries,
the incidence of viral hepatitis is reducing due to advancements in disease prevention …