Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Eukaryotic genomes are highly compacted in the cell nucleus. Two loci separated by a long
linear distance can be brought into proximity in space through DNA-binding proteins and …

Chromatin loops (or chromatin interactions) are important elements of chromatin structures.
Disruption of chromatin loops is associated with many diseases, such as cancer and …

The 3D genome prediction in cancer is crucial for uncovering the impact of structural
variations (SVs) on tumorigenesis, especially when they are present in noncoding regions …

The cancer genome is characterized by extensive variability, in the form of Single Nucleotide
Polymorphisms (SNPs) or structural variations such as Copy Number Alterations (CNAs) …

Cohesin is a multifunctional protein responsible for transcriptional regulation and chromatin
organization. Cohesin binds to chromatin at tens of thousands of distinct sites in a conserved …

Transcription factors (TFs) engage in various cellular essential processes including
differentiation, growth and migration. However, the master TF involved in distant metastasis …

Abstract The three-dimensional (3D) organization of the human genome plays a crucial role
in gene regulation. EXPloration of Regulatory Epigenome with Spatial and Sequence …

The mammalian genome is highly packed into the nucleus. Over the past decade, the
development of Hi-C has contributed significantly to our understanding of the three …