Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

Up to 1.5 million people die yearly from fungal disease, but the repertoire of antifungal drug
classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was …

Proteins of the Hsp110 family are molecular chaperones that play important roles in protein
homeostasis in eukaryotes. The pathogenic fungus Candida albicans, which causes …

In addition to the general interest connected with investigations on biodiversity in natural
contexts, more recently the scientific community has started considering occurrence of …

Fungal infections present a significant global health challenge, prompting ongoing research
to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are …

Pathogenic microorganisms can infect a variety of niches in the human body. During
infection, microbes can only persist if they adapt adequately to the dynamic host …

Hsp110s are unique and essential molecular chaperones in the eukaryotic cytosol. They
play important roles in maintaining cellular protein homeostasis. Candida albicans is the …

Fungal pathogens present a major common threat across human communities: they cause
disease and death in humans, animals, and global food crops. The development of anti …

Grf10, a homeodomain-containing transcription factor, regulates adenylate and one-carbon
metabolism and morphogenesis in the human fungal pathogen Candida albicans. Here, we …

Background: Yeasts from the genus Cryptococcus (species C. neoformans and C. gattii) are
opportunistic pathogens that afflict humans with low immunity caused by diseases such as …