The role of the gut microbiota in NAFLD

C Leung, L Rivera, JB Furness… - … reviews Gastroenterology & …, 2016 - nature.com
NAFLD is now the most common cause of liver disease in Western countries. This Review
explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut …

Early developmental conditioning of later health and disease: physiology or pathophysiology?

MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD

TK Soderborg, SE Clark, CE Mulligan… - Nature …, 2018 - nature.com
Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic
fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early …

Inflammation in maternal obesity and gestational diabetes mellitus

P Pantham, ILMH Aye, TL Powell - Placenta, 2015 - Elsevier
Background The prevalence of maternal obesity is rising rapidly worldwide and constitutes a
major obstetric problem, increasing mortality and morbidity in both mother and offspring …

Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring

P Agarwal, TS Morriseau, SM Kereliuk… - Critical reviews in …, 2018 - Taylor & Francis
Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …

Developmental origins of NAFLD: a womb with a clue

SR Wesolowski, KCE Kasmi, KR Jonscher… - Nature reviews …, 2017 - nature.com
Abstract Changes in the maternal environment leading to an altered intrauterine milieu can
result in subtle insults to the fetus, promoting increased lifetime disease risk and/or disease …

[HTML][HTML] Non-alcoholic fatty liver disease: what the clinician needs to know

MV Machado, H Cortez-Pinto - World journal of gastroenterology …, 2014 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of liver disease in the
Western world. Furthermore, it is increasing worldwide, paralleling the obesity pandemic …

Endocrine-disrupting chemicals and fatty liver disease

CE Foulds, LS Treviño, B York, CL Walker - Nature Reviews …, 2017 - nature.com
A growing epidemic of nonalcoholic fatty liver disease (NAFLD) is paralleling the increase in
the incidence of obesity and diabetes mellitus in countries that consume a Western diet. As …

Developmental programming in response to maternal overnutrition

MZ Alfaradhi, SE Ozanne - Frontiers in genetics, 2011 - frontiersin.org
Metabolic disorders have seen an increased prevalence in recent years in developed as
well as developing countries. While it is clear lifestyle choices and habits have contributed to …

[HTML][HTML] Maternal obesity and the human milk metabolome: associations with infant body composition and postnatal weight gain

E Isganaitis, S Venditti, TJ Matthews, C Lerin… - The American journal of …, 2019 - Elsevier
Background Maternal obesity is a risk factor for childhood obesity; this is a major public
health concern given that∼ 40% of pregnant women are either overweight or obese …