Ruthenium-nitrosyl complexes as NO-releasing molecules, potential anticancer drugs, and photoswitches based on linkage isomerism

I Stepanenko, M Zalibera, D Schaniel, J Telser… - Dalton …, 2022 - pubs.rsc.org
The synthesis of new types of mono-and polynuclear ruthenium nitrosyl complexes is driving
progress in the field of NO generation for a variety of applications. Light-induced Ru-NO …

Metal compounds against neglected tropical diseases

YC Ong, S Roy, PC Andrews, G Gasser - Chemical reviews, 2018 - ACS Publications
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Bioinorganic systems responsive to the diatomic gases O2, NO, and CO: From biological sensors to therapy

LG de Franca Lopes, FSG Júnior, AKM Holanda… - Coordination Chemistry …, 2021 - Elsevier
The diatomic molecules, O 2, NO and CO, have had a myriad of roles in biology. Due to this,
nature has developed many sensing proteins to perceive and respond to changes in the …

Exploring Ruthenium‐Based Organometallic Inhibitors Against Plasmodium Falciparum Calcium Dependent Kinase 2 (PfCDPK2): A Combined Ensemble Docking …

D Patel, M Athar, PC Jha - ChemistrySelect, 2021 - Wiley Online Library
Recent advances in the metal‐organic framework (MOF) have accelerated the discovery of
novel metal‐based anticancer, antibacterial and antimalarial compounds. This is …

Metallodrugs for the treatment of trypanosomatid diseases: Recent advances and new insights

M Navarro, R Justo, GYS Delgado… - Current Pharmaceutical …, 2021 - ingentaconnect.com
Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

FSG Júnior, JA de Moraes Silveira, TM Holanda… - Dalton …, 2023 - pubs.rsc.org
Nitrosyl ruthenium complexes are promising platforms for nitric oxide (NO) and nitroxyl
(HNO) release, which exert their therapeutic application. In this context, we developed two …

Lupeol induces immunity and protective efficacy in a murine model against visceral leishmaniasis

G Kaur, K Chauhan, S Kaur - Parasitology, 2019 - cambridge.org
The available chemotherapeutics for the cure of visceral leishmaniasis (VL) are linked with
many detrimental effects. Moreover, VL is associated with the suppression of protective Th1 …

In vitro and in vivo leishmanicidal activity of a ruthenium nitrosyl complex against Leishmania (Viannia) braziliensis

NRF do Nascimento, FLN de Aguiar, CF Santos… - Acta tropica, 2019 - Elsevier
Leishmaniasis is a parasitic disease caused by protozoa of the genus Leishmania. There
are many complications presented by the current treatment, as high toxicity, high cost and …

Exploring Innovative Leishmaniasis Treatment: Drug Targets from Pre‐Clinical to Clinical Findings

W Santana, SSC de Oliveira, MH Ramos… - Chemistry & …, 2021 - Wiley Online Library
Leishmaniasis is a group of tropical diseases caused by parasitic protozoa belonging to the
genus Leishmania. The disease is categorized in cutaneous leishmaniasis (CL) …

Thiocarbonyl-bound metallonitrosyl complexes with visible-light induced DNA cleavage and promising vasodilation activity

CDS Silva, IA Paz, FD Abreu, AP de Sousa… - Journal of Inorganic …, 2018 - Elsevier
Nitric oxide has been involved in many key biological processes such as vasodilation,
platelet aggregation, apoptosis, memory function, and this has drawn attention to the …