Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …

Heterozygosity for inverted formin-2 (INF2) mutations causes focal segmental
glomerulosclerosis (FSGS) with or without Charcot-Marie-Tooth disease. A key question is …

Proteinuria encompasses diverse causes including both genetic diseases and acquired
forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a …

Two coding variants in the apolipoprotein L1 (APOL1) gene (termed G1 and G2) are strongly
associated with increased risk of nondiabetic kidney disease in people of recent African …

Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration
barrier and withstand high mechanical forces through a complex network of cellular …

Formins are a conserved family of proteins that primarily act to form linear polymers of actin.
Despite their importance to the normal functioning of the cytoskeleton, for a long time, the …

Transient receptor potential cation channel-6 (TRPC6) gene mutations cause familial focal
segmental glomerulosclerosis (FSGS), which is inherited as an autosomal dominant …