Acute-phase protein synthesis: a key feature of innate immune functions of the liver
C Ehlting, SD Wolf, JG Bode - Biological chemistry, 2021 - degruyter.com
The expression of acute-phase proteins (APP's) maintains homeostasis and tissue repair,
but also represents a central component of the organism's defense strategy, especially in the …
but also represents a central component of the organism's defense strategy, especially in the …
Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers
Stem cell-independent reprogramming of differentiated cells has recently been identified as
an important paradigm for repairing injured tissues. Following periportal injury, mature …
an important paradigm for repairing injured tissues. Following periportal injury, mature …
[HTML][HTML] Protocol for primary mouse hepatocyte isolation
M Charni-Natan, I Goldstein - STAR protocols, 2020 - Elsevier
Primary hepatocytes are a vital tool in various biomedical research disciplines, serving as an
ex vivo model for liver physiology. Obtaining high yields of viable primary mouse …
ex vivo model for liver physiology. Obtaining high yields of viable primary mouse …
Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis
Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated
cytokine pathways leading to elevated chemokine expression. Super-enhancers are …
cytokine pathways leading to elevated chemokine expression. Super-enhancers are …
Structures and consequences of pioneer factor binding to nucleosomes
E Luzete-Monteiro, KS Zaret - Current opinion in structural biology, 2022 - Elsevier
Pioneer transcription factors are able to bind a partially exposed motif on the surface of a
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have …
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have …
STAT3 and STAT5 activation in solid cancers
The Signal Transducer and Activator of Transcription (STAT) 3 and 5 proteins are activated
by many cytokine receptors to regulate specific gene expression and mitochondrial …
by many cytokine receptors to regulate specific gene expression and mitochondrial …
The human adenovirus E1B-55K oncoprotein coordinates cell transformation through regulation of DNA-bound host transcription factors
K von Stromberg, L Seddar, WH Ip… - Proceedings of the …, 2023 - National Acad Sciences
The multifunctional adenovirus E1B-55K oncoprotein can induce cell transformation in
conjunction with adenovirus E1A gene products. Previous data from transient expression …
conjunction with adenovirus E1A gene products. Previous data from transient expression …
Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle
The pioneer activity of transcription factors allows for opening of inaccessible regulatory
elements and has been extensively studied in the context of cellular differentiation and …
elements and has been extensively studied in the context of cellular differentiation and …
Regulators of hepcidin expression
MP Roth, D Meynard, H Coppin - Vitamins and hormones, 2019 - Elsevier
Iron, an essential nutrient, is required for many biological processes but is also toxic in
excess. The lack of a mechanism to excrete excess iron makes it crucial for the body to …
excess. The lack of a mechanism to excrete excess iron makes it crucial for the body to …